The effect of tulobuterol patches on the respiratory system after endotracheal intubation
이도원, 김은수, 도왕석, 이한빛, 김은정, 김철홍,
소속 상세정보
이도원 ( Lee Do-Won ) - Pusan National University Hospital Departments of Anesthesia and Pain Medicine
김은수 ( Kim Eun-Soo ) - Pusan National University Hospital Departments of Anesthesia and Pain Medicine
도왕석 ( Do Wang-Seok ) - Pusan National University Hospital Departments of Anesthesia and Pain Medicine
이한빛 ( Lee Han-Bit ) - Pusan National University Hospital Departments of Anesthesia and Pain Medicine
김은정 ( Kim Eun-Jung ) - Pusan National University Dental Hospital Department of Dental Anesthesia and Pain Medicine
김철홍 ( Kim Cheul-Hong ) - Pusan National University Dental Hospital Department of Dental Anesthesia and Pain Medicine
Abstract
Background: Endotracheal intubation during anesthesia induction may increase airway resistance (Raw) and decrease dynamic lung compliance (Cdyn). We hypothesized that prophylactic treatment with a transdermal β2-agonist tulobuterol patch (TP) would help to reduce the risk of bronchospasm after placement of the endotracheal tube.
Methods: Eighty-two American Society of Anesthesiologists (ASA) category I or II adult patients showing obstructive patterns were divided randomly into a control and a TP group (n = 41 each). The night before surgery, a 2-mg TP was applied to patients in the TP group. Standard monitors were recorded, and target controlled infusion (TCI) with propofol and remifentanil was used for anesthesia induction and maintenance. Simultaneously, end-tidal carbon dioxide, Raw, and Cdyn were determined at 5, 10, and 15 min intervals after endotracheal intubation.
Results: There was no significant difference in demographic data between the two groups. The TP group was associated with a lower Raw and a higher Cdyn, as compared to the control group. Raw was significantly lower at 10 min (P < 0.05) and 15 min (P < 0.01), and Cdyn was significantly higher at 5 min (P < 0.05) and 15 min (P < 0.01) in the TP group. A trend towards a lower Raw was observed showing a statistically significant difference 5 min after endotracheal intubation (P < 0.01) in each group.
Conclusions: Prophylactic treatment with TP showed a bronchodilatory effect through suppressing an increase in Raw and a decrease in Cdyn after anesthesia induction without severe adverse effects.
키워드
Bronchospasm; Endotracheal Intubation; Tulobuterol Patch
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